Reducing the burden of recombinant protein production through experimental evolution
University of York
Dr. Caroline Calvert
Fujifilm Diosynth Biotechnologies
In 2015 I moved from Poland to York to undertake my undergraduate studies at University of York. After four years I completed my integrated Master's program in Biomedical Sciences. Throughout those years my interest in microbiology grew, spanning all areas relating to bacteria antibiotic resistance, bacterial communities, their evolution, pathogenesis and industrial applications.
My final year project focused on evolutionary microbiology approach to looking for evidence of collateral sensitivity between bacteriophages and antibiotics in Pseudomonas aeruginosa.
Now, I am starting my PhD studies at the same university. I will use my evolutionary microbiology experience and knowledge to try to figure out how to ameliorate the fitness cost associated with plasmid carriage used to express recombinant proteins in Escherichia coli.